Recent findings and future perspectives on environmental hypersensitivity from an epidemiological perspective, focusing on a domestic survey study of environmental hypersensitivity using the international common questionnaire.
環境過敏症（environmental hypersensitivity）為具有多種全身症狀的健康障礙，包括自主及內分泌症狀、免疫及過敏症狀、慢性疼痛及疲勞、記憶及情緒障礙以及對日常生活外在環境刺激敏感（光、聲音、嗅覺、氣壓、化學性及電磁波）。這些都是病態建築症候群（sick house syndrome)、化學物質過敏症（chemical sensitivity）
Environmental hypersensitivity (environmental intolerance) is a health disorder characterized by a variety of systemic symptoms, including autonomic and endocrine symptoms, immune and allergic symptoms, chronic pain and fatigue, memory and emotional disorders, and hypersensitivity to external environmental stimuli in daily life (light sensitivity, sound sensitivity, smell sensitivity, air pressure sensitivity, chemical sensitivity, and electromagnetic sensitivity). Its typical examples are sick house syndrome, chemical sensitivity, and electromagnetic hypersensitivity. The pathological mechanism of environmental hypersensitivity can be explained by the three-stage hypothesis; genetic, initiation, and triggering stages. The first stage is genetically determined factors related to the stress response. In the second stage, the person is exposed to environmental factors, becoming a susceptible person to be intolerant to environmental stress. In the third stage, environmental stress at a daily level which would not bother normal persons develops a sensitive person with generalized physical problems. In recent years, the rapid increase in the number of patients with environmental hypersensitivity has become a worldwide problem, and a close relationship with allergic diseases has been pointed out, although its pathogenesis remains to be elucidated. Over the past 30 years, Hojo has conducted multifaceted epidemiological investigations, including the preparation of a Japanese translation of the international common questionnaire to evaluate environmental hypersensitivity, confirmation of its reliability and validity, and the setting of screening thresholds unique to Japan. In this paper, we describe the latest findings on environmental hypersensitivity and introduce some of the epidemiological studies conducted by the authors in Japan using the international common questionnaire.
參考資料：Sachiko Hojo, Atsushi Mizukoshi, and Yoshiyuki Kuroiwa: Recent findings and future perspectives on environmental hypersensitivity from an epidemiological perspective, focusing on a domestic survey study of environmental hypersensitivity using the international common questionnaire. The Autonomic Nervous System (accepted 2021/10/22, in press)